有趣的是，Infigratinib最初于2021年获批用于胆管癌，后因适应症开发策略调整而主动撤回。如今，其有望在ACH赛道迎来“第二春”。基于其疗效和口服便利性，BridgeBio在今年的JPM大会上预测，该药Infigratinib将占据ACH治疗市场50%以上的份额。
But after years of building on Web streams — implementing them in both Node.js and Cloudflare Workers, debugging production issues for customers and runtimes, and helping developers work through far too many common pitfalls — I've come to believe that the standard API has fundamental usability and performance issues that cannot be fixed easily with incremental improvements alone. The problems aren't bugs; they're consequences of design decisions that may have made sense a decade ago, but don't align with how JavaScript developers write code today.
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